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1

BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised

Raaijmakers, Jonne A., van Heesbeen, Roy G.H.P., Blomen, Vincent A., Janssen, Louise M.E., van Diemen, Ferdy, Brummelkamp, Thijn R., Medema, René H.

Journal:

Year:

2018

Language:

english

File:

PDF, 5.28 MB

english, 2018

2

KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses

Staring, Jacqueline, van den Hengel, Lisa G., Raaben, Matthijs, Blomen, Vincent A., Carette, Jan E., Brummelkamp, Thijn R.

Journal:

Cell Host & Microbe

Year:

2018

Language:

english

File:

PDF, 10.96 MB

english, 2018

3

Viral escape from endosomes and host detection at a glance

Staring, Jacqueline, Raaben, Matthijs, Brummelkamp, Thijn R.

Journal:

Journal of Cell Science

Year:

2018

Language:

english

File:

PDF, 944 KB

english, 2018

4

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

Brummelkamp, Thijn R., Nijman, Sebastian M. B., Dirac, Annette M. G., Bernards, René

Journal:

Year:

2003

Language:

english

File:

PDF, 392 KB

english, 2003

5

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

Berns, Katrien, Hijmans, E. Marielle, Mullenders, Jasper, Brummelkamp, Thijn R., Velds, Arno, Heimerikx, Mike, Kerkhoven, Ron M., Madiredjo, Mandy, Nijkamp, Wouter, Weigelt, Britta

Journal:

Year:

2004

Language:

english

File:

PDF, 656 KB

english, 2004

6

Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

Johnnidis, Jonathan B., Harris, Marian H., Wheeler, Robert T., Stehling-Sun, Sandra, Lam, Michael H., Kirak, Oktay, Brummelkamp, Thijn R., Fleming, Mark D., Camargo, Fernando D.

Journal:

Year:

2008

Language:

english

File:

PDF, 774 KB

english, 2008

7

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence

Peeper, Daniel S., Shvarts, Avi, Brummelkamp, Thijn, Douma, Sirith, Koh, Eugene Y., Daley, George Q., Bernards, René

Journal:

Nature Cell Biology

Year:

2002

Language:

english

File:

PDF, 435 KB

english, 2002

8

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors

Brummelkamp, Thijn R, Fabius, Armida W M, Mullenders, Jasper, Madiredjo, Mandy, Velds, Arno, Kerkhoven, Ron M, Bernards, René, Beijersbergen, Roderick L

Journal:

Nature Chemical Biology

Year:

2006

Language:

english

File:

PDF, 424 KB

english, 2006

9

shRNA libraries and their use in cancer genetics

Bernards, René, Brummelkamp, Thijn R, Beijersbergen, Roderick L

Journal:

Year:

2006

Language:

english

File:

PDF, 320 KB

english, 2006

10

Innovation: New tools for functional mammalian cancer genetics

Brummelkamp, Thijn R., Bernards, René

Journal:

Nature Reviews Cancer

Year:

2003

Language:

english

File:

PDF, 524 KB

english, 2003

11

Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector

van de Wetering, Marc, Oving, Irma, Muncan, Vanesa, Pon Fong, Menno Tjon, Brantjes, Helen, van Leenen, Dik, Holstege, Frank C.P., Brummelkamp, Thijn R., Agami, Reuven, Clevers, Hans

Journal:

Year:

2003

Language:

english

File:

PDF, 278 KB

english, 2003

12

E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains

Logan, Nicola, Delavaine, Laurent, Graham, Anne, Reilly, Carmel, Wilson, Jon, Brummelkamp, Thijn R, Hijmans, E Marielle, Bernards, René, La Thangue, Nicholas B

Journal:

Year:

2004

Language:

english

File:

PDF, 620 KB

english, 2004

13

YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells

Fernando D. Camargo, Sumita Gokhale, Jonathan B. Johnnidis, Dongdong Fu, George W. Bell, Rudolf Jaenisch, Thijn R. Brummelkamp

Journal:

Current Biology

Year:

2007

Language:

english

File:

PDF, 18 KB

english, 2007

14

YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells

Fernando D. Camargo, Sumita Gokhale, Jonathan B. Johnnidis, Dongdong Fu, George W. Bell, Rudolf Jaenisch, Thijn R. Brummelkamp

Journal:

Current Biology

Year:

2007

Language:

english

File:

PDF, 1.96 MB

english, 2007

15

Haploid genetic screening to identify novel regulators of MHC class I antigen presentation

Robbert Spaapen, Vincent Blomen, Matthijs Raaben, Thijn Brummelkamp, Jacques Neefjes

Journal:

Molecular Immunology

Year:

2012

Language:

english

File:

PDF, 56 KB

english, 2012

16

Stable suppression of tumorigenicity by virus-mediated RNA interference

Thijn R Brummelkamp, René Bernards, Reuven Agami

Journal:

Year:

2002

Language:

english

File:

PDF, 199 KB

english, 2002

17

A Genomic and Functional Inventory of Deubiquitinating Enzymes

Sebastian M.B. Nijman, Mark P.A. Luna-Vargas, Arno Velds, Thijn R. Brummelkamp, Annette M.G. Dirac, Titia K. Sixma, René Bernards

Journal:

Year:

2005

Language:

english

File:

PDF, 1.15 MB

english, 2005

18

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

Karin Schlegelmilch, Morvarid Mohseni, Oktay Kirak, Jan Pruszak, J. Renato Rodriguez, Dawang Zhou, Bridget T. Kreger, Valera Vasioukhin, Joseph Avruch, Thijn R. Brummelkamp, Fernando D. Camargo

Journal:

Year:

2011

Language:

english

File:

PDF, 3.36 MB

english, 2011

19

The Deubiquitinating Enzyme USP1 Regulates the Fanconi Anemia Pathway

Sebastian M.B. Nijman, Tony T. Huang, Annette M.G. Dirac, Thijn R. Brummelkamp, Ron M. Kerkhoven, Alan D. D'Andrea, René Bernards

Journal:

Year:

2005

Language:

english

File:

PDF, 619 KB

english, 2005

20

Genes that allow escape from senescence

Daniel Peeper, Avi Shvarts, Thijn Brummelkamp, Benjamin Rowland, Roderick Kortlever, Sirith Douma, René Bernards

Journal:

European Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 170 KB

english, 2001

21

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

Birsoy, Kivanç, Wang, Tim, Possemato, Richard, Yilmaz, Omer H, Koch, Catherine E, Chen, Walter W, Hutchins, Amanda W, Gultekin, Yetis, Peterson, Tim R, Carette, Jan E, Brummelkamp, Thijn R, Clish, Cla

Journal:

Nature Genetics

Year:

2012

Language:

english

File:

PDF, 730 KB

english, 2012

22

Functional genetic screens to identify cancer relevant genes

Thijn R. Brummelkamp

Journal:

European Journal of Cancer Supplements

Year:

2007

Language:

english

File:

PDF, 48 KB

english, 2007

23

A CREB3–ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens

Reiling, Jan H., Olive, Andrew J., Sanyal, Sumana, Carette, Jan E., Brummelkamp, Thijn R., Ploegh, Hidde L., Starnbach, Michael N., Sabatini, David M.

Journal:

Nature Cell Biology

Year:

2013

Language:

english

File:

PDF, 2.79 MB

english, 2013

24

Elucidating the molecular mechanism of action of cancer drugs in the second decade of the new millennium

Superti-Furga, Giulio, Winter, Georg, Bigenzahn, Johannes, Radic, Branka, Colinge, Jacques, Bennett, Keiryn, Kubicek, Stefan, Zuber, Johannes, Brummelkamp, Thijn, Huber, Kilian

Journal:

Experimental Hematology

Year:

2013

Language:

english

File:

PDF, 44 KB

english, 2013

25

Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells

Chen, Walter W., Birsoy, Kıvanç, Mihaylova, Maria M., Snitkin, Harriet, Stasinski, Iwona, Yucel, Burcu, Bayraktar, Erol C., Carette, Jan E., Clish, Clary B., Brummelkamp, Thijn R., Sabatini, David D.,

Journal:

Year:

2014

Language:

english

File:

PDF, 1.77 MB

english, 2014

26

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

Essletzbichler, Patrick, Konopka, Tomasz, Santoro, Federica, Chen, Doris, Gapp, Bianca V., Kralovics, Robert, Brummelkamp, Thijn R., Nijman, Sebastian M.B., Bürckstümmer, Tilmann

Journal:

Genome Research

Year:

2014

Language:

english

File:

PDF, 1009 KB

english, 2014

27

Dissecting the role of aberrant DNA methylation in human leukaemia

Amabile, Giovanni, Di Ruscio, Annalisa, Müller, Fabian, Welner, Robert S., Yang, Henry, Ebralidze, Alexander K., Zhang, Hong, Levantini, Elena, Qi, Lihua, Martinelli, Giovanni, Brummelkamp, Thijn, Le

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 1.35 MB

english, 2015

28

Emerging intracellular receptors for hemorrhagic fever viruses

Jae, Lucas T., Brummelkamp, Thijn R.

Journal:

Trends in Microbiology

Year:

2015

Language:

english

File:

PDF, 1.59 MB

english, 2015

29

Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis In Vivo

Herbert, Andrew S., Davidson, Cristin, Kuehne, Ana I., Bakken, Russell, Braigen, Stephen Z., Gunn, Kathryn E., Whelan, Sean P., Brummelkamp, Thijn R., Twenhafel, Nancy A., Chandran, Kartik, Walkley, S

Journal:

Year:

2015

Language:

english

File:

PDF, 2.54 MB

english, 2015

30

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

Jan H. Reiling, Clary B. Clish, Jan E. Carette, Malini Varadarajan, Thijn R. Brummelkamp and David M. Sabatini

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 2.84 MB

english, 2011

31

Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT)

Panagiotis Papatheodorou, Jan E. Carette, George W. Bell, Carsten Schwan, Gregor Guttenberg, Thijn R. Brummelkamp and Klaus Aktories

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.49 MB

english, 2011

32

Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion

Kleinfelter, Lara M., Jangra, Rohit K., Jae, Lucas T., Herbert, Andrew S., Mittler, Eva, Stiles, Katie M., Wirchnianski, Ariel S., Kielian, Margaret, Brummelkamp, Thijn R., Dye, John M., Chandran, Kar

Journal:

Year:

2015

Language:

english

File:

PDF, 2.98 MB

english, 2015

33

A generic strategy for CRISPR-Cas9-mediated gene tagging

Lackner, Daniel H., Carré, Alexia, Guzzardo, Paloma M., Banning, Carina, Mangena, Ramu, Henley, Tom, Oberndorfer, Sarah, Gapp, Bianca V., Nijman, Sebastian M.B., Brummelkamp, Thijn R., Bürckstümmer, T

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 572 KB

english, 2015

34

Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling

Brockmann, Markus, Blomen, Vincent A., Nieuwenhuis, Joppe, Stickel, Elmer, Raaben, Matthijs, Bleijerveld, Onno B., Altelaar, A. F. Maarten, Jae, Lucas T., Brummelkamp, Thijn R.

Journal:

Year:

2017

Language:

english

File:

PDF, 7.19 MB

english, 2017

35

A haploid mammalian genetic screen identifies UBXD8 as a key determinant of sterol-stimulated degradation of HMGCR and cholesterol synthesis

Loregger-Wiesmann, Anke, Raaben, Matthijs, Tan, Josephine, Scheij, Saskia, Moeton, Martina, Gelberg, Hela, Stickel, Elmer, Roitelman, Joseph, Brummelkamp, Thijn, Zelcer, Noam

Journal:

Atherosclerosis

Year:

2017

Language:

english

File:

PDF, 53 KB

english, 2017

36

Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis

Loregger, Anke, Raaben, Matthijs, Tan, Josephine, Scheij, Saskia, Moeton, Martina, van den Berg, Marlene, Gelberg-Etel, Hila, Stickel, Elmer, Roitelman, Joseph, Brummelkamp, Thijn, Zelcer, Noam

Journal:

Arteriosclerosis Thrombosis and Vascular Biology

Year:

2017

Language:

english

File:

PDF, 23.16 MB

english, 2017

37

Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread

Hoffmann, H.-Heinrich, Schneider, William M., Blomen, Vincent A., Scull, Margaret A., Hovnanian, Alain, Brummelkamp, Thijn R., Rice, Charles M.

Journal:

Cell Host & Microbe

Year:

2017

Language:

english

File:

PDF, 2.40 MB

english, 2017

38

NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry

Raaben, Matthijs, Jae, Lucas T., Herbert, Andrew S., Kuehne, Ana I., Stubbs, Sarah H., Chou, Yi-ying, Blomen, Vincent A., Kirchhausen, Tomas, Dye, John M., Brummelkamp, Thijn R., Whelan, Sean P.

Journal:

Cell Host & Microbe

Year:

2017

Language:

english

File:

PDF, 3.80 MB

english, 2017

39

Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents

Gerhards, Nora M., Blomen, Vincent A., Mutlu, Merve, Nieuwenhuis, Joppe, Howald, Denise, Guyader, Charlotte, Jonkers, Jos, Brummelkamp, Thijn R., Rottenberg, Sven

Journal:

Molecular Oncology

Year:

2018

Language:

english

File:

PDF, 1.66 MB

english, 2018

40

A Reporter Screen in a Human Haploid Cell Line Identifies CYLD as a Constitutive Inhibitor of NF-κB

Lee, Clarissa C., Carette, Jan E., Brummelkamp, Thijn R., Ploegh, Hidde L., Poltorak, Alexander

Journal:

Year:

2013

Language:

english

File:

PDF, 933 KB

english, 2013

41

Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores

Janssen, Louise M.E., Averink, Tessa V., Blomen, Vincent A., Brummelkamp, Thijn R., Medema, René H., Raaijmakers, Jonne A.

Journal:

Current Biology

Year:

2018

File:

PDF, 3.21 MB

2018

42

Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores

Janssen, Louise M.E., Averink, Tessa V., Blomen, Vincent A., Brummelkamp, Thijn R., Medema, René H., Raaijmakers, Jonne A.

Journal:

Current Biology

Year:

2018

Language:

english

File:

PDF, 3.21 MB

english, 2018

43

The Tubulin Detyrosination Cycle: Function and Enzymes

Nieuwenhuis, Joppe, Brummelkamp, Thijn R.

Journal:

Trends in Cell Biology

Year:

2018

Language:

english

File:

PDF, 2.62 MB

english, 2018

44

Nedd4 Binding Protein 1 (N4BP1) and TNFAIP3 Interacting Protein 1 (TNIP1) control MHC-1 display in neuroblastoma

Spel, Lotte, Nieuwenhuis, Joppe, Haarsma, Rianne, Stickel, Elmer, Bleijerveld, Onno B, Altelaar, Maarten, Boelens, Jaap Jan, Brummelkamp, Thijn R, Nierkens, Stefan, Boes, Marianne

Journal:

Cancer Research

Year:

2018

Language:

english

File:

PDF, 7.66 MB

english, 2018

45

A genome-wide haploid genetic screen identifies heparan sulfate-associated genes and the macropinocytosis modulator TMED10 as factors supporting vaccinia virus infection

Luteijn, Rutger D., van Diemen, Ferdy, Blomen, Vincent A., Boer, Ingrid G.J., Manikam Sadasivam, Saravanan, van Kuppevelt, Toin H., Drexler, Ingo, Brummelkamp, Thijn R., Lebbink, Robert Jan, Wiertz, E

Journal:

Journal of Virology

Year:

2019

Language:

english

File:

PDF, 3.17 MB

english, 2019

46

A genome-wide haploid genetic screen identifies heparan sulfate-associated genes and the macropinocytosis modulator TMED10 as factors supporting vaccinia virus infection

Luteijn, Rutger D., van Diemen, Ferdy, Blomen, Vincent A., Boer, Ingrid G.J., Manikam Sadasivam, Saravanan, van Kuppevelt, Toin H., Drexler, Ingo, Brummelkamp, Thijn R., Lebbink, Robert Jan, Wiertz, E

Journal:

Journal of Virology

Year:

2019

File:

PDF, 3.17 MB

2019

47

Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1–SVBP

Adamopoulos, Athanassios, Landskron, Lisa, Heidebrecht, Tatjana, Tsakou, Foteini, Bleijerveld, Onno B., Altelaar, Maarten, Nieuwenhuis, Joppe, Celie, Patrick H. N., Brummelkamp, Thijn R., Perrakis, An

Journal:

Nature Structural and Molecular Biology

Year:

2019

Language:

english

File:

PDF, 4.14 MB

english, 2019

48

Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1–SVBP

Adamopoulos, Athanassios, Landskron, Lisa, Heidebrecht, Tatjana, Tsakou, Foteini, Bleijerveld, Onno B., Altelaar, Maarten, Nieuwenhuis, Joppe, Celie, Patrick H. N., Brummelkamp, Thijn R., Perrakis, An

Journal:

Nature Structural and Molecular Biology

Year:

2019

File:

PDF, 4.14 MB

2019

49

Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway

De Zan, Erica, van Stiphout, Ruud, Gapp, Bianca V., Blomen, Vincent A., Brummelkamp, Thijn R., Nijman, Sebastian M.B.

Journal:

Science Signaling

Year:

2020

File:

PDF, 1.10 MB

2020